Material
Synthetic 60% Hydroxyapatite (HA)
40% β-Tricalcium Phosphate (β-TCP)
INDICATION
Bone substitute material
Variants
As granules or as putty
(hydrogel-based)
TIXXU Graft
synthetic bone substitute
TIXXU GRAFT Materials from MBCPTMTECHNOLOGY
The micro-macroporous biphasic calcium phosphate mimics the structure of a natural bone.
Biomimetic surface
Safe solution – biocompatible – Synthetic
Safe solution – biocompatible – Synthetic
Characteristics
Material
Synthetic 60% Hydroxyapatite (HA)
40% β-Tricalcium Phosphate (β-TCP)
INDICATION
Bone substitute material
Variants
As granules or as putty
(hydrogel-based)
Ideal bone substitute
-
Harvesian system
Lamelar bone
- Slow and gradual biodegradation by biodissolution + bioresorption
- Macroporous
- Microporous
Fully permeable matrix
TIXXU GRAFT bone substitute-putty
TIXXU GRAFT is not only available as granules, but also in a gel variant (putty).
TIXXU GRAFT putty is a malleable and injectable synthetic bone substitute material consisting of biphasic calcium phosphate granules (≥ 50% HA/β-TCP) in combination with a hydrogel.
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How to use it
- Hydratation of the granules
- prehydrate with saline solution (to avoid osmotic shock)
- TIXXU GRAFT
- must be brought into contact with living bone
- Never compress or press together
- otherwise the porosity would be damaged
- Healing
- pay attention to the bone growth cycle: 5 to 8 months is recommended The implant is inserted after approximately 6 months
- Important
- only use the right amount of granules. Never overfill.
- To read the complete precautions, please refer to the Instructions of Use (see brochure)
- No hydratation required
- ready to use
- Vascularization
- must be brought into contact with living bone
- Covering
- with an resorbable membrane to fix the graft and protect it from soft-tissue colonization (GBR)
- Important
- the material must be introduced with maximum direct bone contact
- To read the complete precautions, please refer to the Instructions of Use (see brochure)
Literature
1. Daculsi G, Laboux O, Malard O, Weiss P. Current state of the art of biphasic calcium phosphate bioceramics. J Mater Sci Mater Med. (2003) Mar;14(3):195-200
2. Daculsi G. , LeGeros R. Z, Grimandi G., Soueidan A., Aguado E., Goyenvalle E., LeGeros J., Effect of Sintering Process of HA/TCP Bioceramics on Microstructure, Dissolution, Cell Proliferation and Bone Ingrowth, Key Engineering materials Vols 361-363 (2008) pp1139-1142
3. Changseong K., Sung Cho K., Daculsi C., Seris E. , Daculsi G., Eight-Year Clinical Follow-Up of Sinus Grafts with Micro-Macroporous Biphasic Calcium Phosphate Granules, Key Engineering Materials Vol. 587 (2014) pp 321-324
4. Rodriguez C., Jean A., Daculsi G., Five Years Clinical Follow up Bone Regeneration with CaP Bioceramics, Key Engineering Materials Vols. 361-363 (2008) pp. 1339-1342
5. Daculsi G., Jegoux F. and Layrolle P., The micro macroporous biphasic calcium phosphate concept for bone reconstruction and tissue engineering. in Advanced Biomaterials: Fundamentals, Processing, and Applications book, Basu B. et al., Wiley J. and sons Inc., (2009) pp 101-141
6. Fellah B., Gauthier O., Weiss P., Chappard, D. Layrolle P., Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model, Biomaterials 29 (2008) 1177-1188
7. Lee JH, Jung UW, Kim CS, Choi SH, Cho KS., Histologic and clinical evaluation for maxillary sinus augmentation using macroporous biphasic calcium phosphate in human, Clin Oral Implants Res. (2008) Aug;19(8):767-71.
8. Daculsi G., Layrolle P., Osteoinductive properties of Micro Macroporous biphasic calcium phosphate bioceramics., Key Engineering Materials (2004);254-256:1005-8.
